Establishment of oocyte population in the fetal ovary: primordial germ cell proliferation and oocyte programmed cell death
نویسندگان
چکیده
منابع مشابه
The effect of BMP4 on mouse embryonic stem cell proliferation and differentiation into primordial germ cells
Background and Aim: Artificial gamete production from stem cells is a novel strategy for treatment of infertility. Among various stem cell sources, embryonic stem cells (ESC) can be considered as an appropriate source for in vitro formation of germ cells. In this study we evaluated the effect of BMP4 on proliferation and differentiation of mouse embryonic stem cells into primordial germ cells (...
متن کاملMolecular markers of oocyte and primordial germ cell development in the sea urchin
Beginning over 150 years ago, sea urchins have been an essential experimental tool for our understanding of fertilization and early development. Here we summarize our recent progress on the molecular mechanisms of oocyte development and fertilization in the sea urchin resulting from completing the sequence of the purple sea urchin genome. This genomic information has enabled us to predict gene ...
متن کاملSkin-derived stem cells as a source of primordial germ cell- and oocyte-like cells
The skin is a unique organ that contains a variety of stem cells for the maintenance of skin homeostasis and the repair of skin tissues following injury and disease. Skin-derived stem cells (SDSCs) constitute a heterogeneous population of stem cells generated in vitro from dermis, which can be cultured as spherical aggregates of cells in suspension culture. Under certain in vitro or in vivo con...
متن کاملBMP Signaling in the Human Fetal Ovary is Developmentally Regulated and Promotes Primordial Germ Cell Apoptosis
Primordial germ cells (PGCs) are the embryonic precursors of gametes in the adult organism, and their development, differentiation, and survival are regulated by a combination of growth factors collectively known as the germ cell niche. Although many candidate niche components have been identified through studies on mouse PGCs, the growth factor composition of the human PGC niche has not been s...
متن کاملAn investigation of primordial germ cell development in embryo and larvae of Huso huso
In sturgeons, Primordial Germ Cells originate from the vegetal pole of the egg. They migrate toward genital ridges during developmental stages and finally differentiate into gametes (the only cells that transmit genetic information). In this study, the cells were isolated from the place of migration of primordial germ cells in Huso huso’s larvae during two stages before and after absorption of ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Reproductive BioMedicine Online
سال: 2005
ISSN: 1472-6483
DOI: 10.1016/s1472-6483(10)60939-x